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KMID : 0607520050130020085
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Korean Journal of Psychosomatic Medicine
2005 Volume.13 No. 2 p.85 ~ p.94
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A Prospective and Open-Label Trial of Quetiapine and Haloperidol in the Treatment of Delirium
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Choi Hag-Gyu
Park Byoung-Sun
Lee Hyun-Jung
Choi Jin-Sook
Jho Kyeong-Hyeong
Shin Young-Min
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Abstract
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Objectives: This prospective and open-label study was conducted to evaluate the efficacy and safety of quetiapine and haloperidol in patients with delirium.
Methods: Fourty patients(19 patients in a quetiapine group : 21 patients in a haloperidol group) with delirium by DSM-IV were treated with flexible doses of open-label qvetiapine and haloperidol. To evaluate the primary efficacy of the medication, scores from the Korean version of Delirium Rating Scale(K-DRS) were assessed every seven days and to evaluate the secondary efficacy and safety, scores from the Clinical Global Impression-Severity, Korean Version of Mini-Mental State Examination, and the Drug-Induced Extrapyramidal Symptoms Scale were assessed at the baseline and the seventh day. Data were gathered from November 2004 to June 2005.
Results: K-DRS scores for each group decreased significantly over the study period; however, no significant differences between groups were found. The group-by-time effect was not significant. In addition, there was no significant difference in the frequency of response to drugs between the two groups. No patients reported clinically significant side effects.
Conclusion: These data show no significant difference in the efficacy and safety between quetiapine and haloperidol in the treatment of delirium. Since haloperidol has a great possibility of causing a extrapyramidal side effect resulted by previous studies, it is expected that quetiapine, a renowned medication with low side effects, may be a useful alternative agent to haloperidol, the classical antipsy-chotics, in the treatment of delirium.
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KEYWORD
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Delirium, Quetiapine, Haloperidol
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